Gating of a pH-sensitive K(2P) potassium channel by an electrostatic effect of basic sensor residues on the selectivity filter.

K(+) channels share common selectivity characteristics but exhibit a wide diversity in how they are gated open.Leak K(2P) K(+) channels TASK-2, TALK-1 and TALK-2 are gated open by extracellular alkalinization.The mechanism for this alkalinization-dependent gating has been proposed to be the neutralization of the side chain of a single arginine (lys

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Default Agnosticism

Agnosticism has always had its fair amount of criticism.Religious believers often described the first agnostics as infidels and it is not uncommon GOAT WHOLE MILK to see them described as somewhat dull fence-sitters.Moreover, the undecided agnostic stance on belief in gods is often compared with being unsure about such obviously false statements as

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